Organoids, Organ-on-Chip, and In Silico Models have transformed biomedical and pharmaceutical research, marking a new era of experimentation. Organoids mimic the structure and function of organs, providing a physiologically human-relevant platform for disease study and drug testing. Organ-on-Chip systems replicate human organ microenvironments, offering dynamic conditions for drug assessment. In Silico Models, driven by computational simulations, expedite drug discovery by analyzing complex biological processes. These models contribute to accurate, efficient, and human-centered research, reducing reliance on animal testing and advancing biomedical and pharmaceutical sciences. The 3R-Center Tübingen for In vitro Models and Alternatives to Animal Testing at the University of Tübingen and the NMI Natrual and Medical Sciences Institute in Reutlingen is thrilled to host the first 3R LÄND Conference in the heart of the Länd, Tübingen, Germany. The conference unites academia, clinicians, industry representatives, regulatory agencies, and policymakers in the biomedical and pharmaceutical field. We invite all interested parties to join us on May 21-23, 2024, for a deep dive into the forefront of biomedical and pharmaceutical research. Engage in exciting keynote lectures, scientific presentations, poster sessions, and networking opportunities for interdisciplinary exchange.